Friday, September 14 | Saturday, September 15 | Sunday, September 16

Agenda: Preliminary Program

(Updated: March 5, 2018)

Friday, September 14, 2018

7:30 am Registration is Open
(Grand Ballroom pre-function)
Note: All general sessions are held in the Grand Ballroom Salon I-II
Clinical Outcomes and Outreach in Cancer Cachexia
Chair: Jose Garcia, MD, PhD – VA Puget Sound and University of Washington, USA
Session A: Current Standard of Care in Cancer Cachexia
8:20 am Introductory Remarks
8:30 am Egidio Del Fabbro, MD
Virginia Commonwealth University, USA
Practical considerations of running a successful cancer cachexia clinic

9:00 am Eduardo Bruera, MD
University of Texas, MD Anderson Cancer Center, USA
Palliative care in cancer cachexia

9:30 am Richard Skipworth, MD
University of Edinburgh, United Kingdom
Update on the definition of cancer cachexia and update on clinical trials
10:00 am Coffee Break
Session B: Clinical Trial Design and Outcome Measures in Cancer Cachexia
10:30 am Andrew Hendifar, MD
Cedars-Sinai Medical Center, USA
Focus on pancreatic cancer cachexia: clinical trials in progress
11:00 am Vickie Baracos, PhD
University of Alberta, Canada
Current experience with inclusion and exclusion criteria in cancer cachexia clinical trials: effects on patient eligibility and completion of study intervention
11:30 am Christopher Hartshorn, PhD
National Cancer Institute, USA
Widgets to cancer patient-specific digits: the case for out-of-clinic objective measures and their potential impact to longitudinal discovery in cancer cachexia
12:00 pm Panel Discussion
12:30 pm Lunch
Box lunches will be provided
Session C: Conversations with Caregivers and Patients
Moderator: Marion Couch, MD, PhD – Indiana University School of Medicine, USA
1:30–3:00 pm Program for Caregivers and Patients
– Open to the public; pre-registration required
(Grand Ballroom Salon I-II)

2:30–6:00 pm Poster Set Up
(Grand Ballroom Salon III)

Session 1 –
Introductory Remarks and Keynote Address
Chair: Vickie Baracos, PhD – University of Alberta, Canada
3:45 pm Introductions to the 4th Cancer Cachexia Conference
Denis Guttridge, PhD
Ohio State University, USA
4:00 pm Keynote Address
Josep Argiles, PhD
University of Barcelona, Spain
Past, present, and future of cancer cachexia research
5:00 pm Cutting Edge Science in Cancer Cachexia
Six speakers chosen from selected abstracts
5:30-7:30 pm Welcoming Reception
(Grand Ballroom Salon III)
7:30 pm Poster Viewing
(Grand Ballroom Salon III)

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Saturday, September 15, 2018

6:30-8:30 am Breakfast
(Georgian Room)
Note: All general sessions are held in the Grand Ballroom Salon I-II
Session 2 –
Updates on Developing Models of Cancer Cachexia
Chair: Simon Wing, MD – McGill University, Canada
8:30 am Jose Trevino, MD
University of Florida, USA
PDX models of pancreatic cancer-induced cachexia
9:00 am Speaker: TBA
  Selected Short Talks
9:30 am
9:45 am
Short Talk 1 (selected from abstracts)
Short Talk 2 (selected from abstracts)
10:30 am Coffee Break
(Grand Ballroom Salon III)
Session 3 –
Mechanisms of Muscle Wasting: Part I
Chair: Paul Gregorevic, PhD – Baker Heart and Diabetes Institute, Australia
11:00 am Yi-Ping Li, PhD
University of Texas Health Science Center, USA
Mechanism of pancreatic cancer induction of muscle wasting
11:30 am Andrew Judge, PhD
University of Florida, USA
Forkhead proteins and muscle wasting
12:00 pm Marco Sandri, MD
Padua University, Italy
Novel players in muscle wasting
12:30 pm Lunch
(Georgian Room)
1:45-3:45 pm Poster Viewing
(Grand Ballroom Salon III)
Session 4 –
Organ Cross Talk in Cancer Cachexia
Chair: James Carson, PhD – University of South Carolina, USA
4:00 pm Maria Rohm, PhD
Helmholtz Cancer Center, Germany
AMPK action in adipose wasting in cancer cachexia
4:30 pm Daniel Marks, MD, PhD
Oregon Health Sciences University, USA
Hypothalamic signaling in regulating muscle loss in cancer cachexia
5:00 pm Bernard Allan, PhD
NGM Biopharmaceuticals Inc., USA
GFRAL-dependent nervous system activation by GDF-15 in anorexia and cachexiar
5:30 pm Marilia Seelaender, PhD
University of São Paulo, Brazil
Cachexia-associated alterations in the gut microbiota of cancer patients: can exercise restore the balance?
6:00 pm End of program day

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Sunday, September 16, 2018

6:30-8:30 am Breakfast
(Georgian Room)
Session 5 –
Analysis of Big Data
Chair: Melinda Sheffield-Moore, PhD – Texas A&M University, USA
8:30 am Ben Zeskind, PhD, MBA
Immuneering Inc., USA
Data-driven identification and optimization of new medicines for cancer cachexia
9:00 am Sambasivarao Damaraju, PhD
University of Alberta, Canada
Genetic signatures in cancer cachexia
  Selected Short Talks
9:30 am
9:45 am
Short Talk 3 (selected from abstracts)
Short Talk 4 (selected from abstracts)
10:00 am Coffee Break
Announcement of Poster Winners
(Grand Ballroom Salon III)
Session 6 –
Next Generation Researchers in Cancer Cachexia
Neil Johns, MD – University of Edinburgh, UK,
Erin Talbert, PhD – Ohio State University, USA
To promote upcoming and young faculty researchers: Speakers chosen from submitted applications
10:30 am
10:45 am
11:00 am
11:15 am
11:30 am
11:45 am
Speaker 1 – TBA
Speaker 2 – TBA
Speaker 3 – TBA
Speaker 4 – TBA
Speaker 5 – TBA
Speaker 6 – TBA
12:00 pm Lunch
(Georgian Room)
Session 7 –
Mechanisms of Muscle Wasting: Part II
Chair: Paola Costelli, PhD – University of Turin, Italy
1:30 pm Esther Barreiro, PhD
University of Barcelona, Spain
Novel therapeutic strategies in cancer cachexia: role of PARP and other targets
2:00 pm Teresa Zimmers, PhD
Indiana University School of Medicine, USA
Shh signaling in cancer-induced muscle wasting
2:30 pm David Glass, MD
Novartis Institutes for Biomedical Research, USA
Molecular activation of mitochondrial signaling: good or bad for cachexia?
3:00 pm Coffee Break
(Grand Ballroom Salon III)
Session 8 –
Identification of Biomarkers in Cancer Cachexia
Chair: David Thomas, MD – Broad Institute, USA
3:30 pm Jean-Paul Thissen, PhD
Université catholique de Louvain, Belgium
Activin as a biomarker of cachexia and survival in cancer patients
4:00 pm Ng Shyh-Chang, PhD
Genome Institute of Singapore, Singapore
Fatty acid oxidation during cancer cachexia
  Selected Short Talks
4:30 pm
4:45 pm
Short Talk 5 (selected from abstracts)
Short Talk 6 (selected from abstracts)
5:00 pm Giuseppina Caretti, PhD
University of Milan, Italy
Epigenetic targeting of BET proteins to ameliorate cancer cachexia
5:30 pm Closing Remarks

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